

Villagers return home after receiving new mosquito nets in the Massinga district of Inhambane, Mozambique.
Grand Challenges is a family of initiatives fostering innovation to address key global health and development priorities.
InitiativeGrand ChallengesApplications ClosesApr 28, 2026Learn More Breakthrough Innovations to Significantly Reduce the Cost of Severe Acute Malnutrition Treatment
Novel Interventions Targeting Placental and Gut Inflammation to Improve Fetal Growth
InitiativeGrand ChallengesApplications ClosesApr 28, 2026Learn More Novel Interventions Targeting Placental and Gut Inflammation to Improve Fetal Growth
Artificial Intelligence (AI) to Accelerate Charitable Giving
InitiativeGrand ChallengesApplications ClosesApr 28, 2026Learn More Artificial Intelligence (AI) to Accelerate Charitable Giving
Innovations in Cost-Disruptive Tools for Diagnosis and Screening
InitiativeGrand ChallengesApplications ClosesApr 28, 2026Learn More Innovations in Cost-Disruptive Tools for Diagnosis and Screening
Cost-Disrupting Innovations to Reduce the Cost of Ready-to-Use Therapeutic Food
InitiativeGrand ChallengesApplications ClosesApr 28, 2026Learn More Cost-Disrupting Innovations to Reduce the Cost of Ready-to-Use Therapeutic Food
Addressing Physiological Barriers to Micronutrient Absorption from Fortified Foods
InitiativeGrand ChallengesApplications ClosesApr 28, 2026Learn More Addressing Physiological Barriers to Micronutrient Absorption from Fortified Foods
What's New
Professor Abdoulaye Djimdé Named to UN Secretary General's Scientific Advisory Board
Professor Abdoulaye Djimdé has been appointed to the United Nations Secretary-General's Scientific Advisory Board, marking an important step in elevating African leaders' voices in global research and science policy conversations.
A leading expert in malaria genomics and drug resistance, Prof. Djimdé is focused on building research capacity and scientific collaboration across the continent. He embodies the Calestous Juma Science Leadership Fellowship's vision to cultivate scientists who not only drive innovation but also guide decision-making and international cooperation.
At a time when the world faces increasingly complex health and development challenges, Prof. Djimdé will bring an important and unique perspective to the board's work on science, technology, and innovation for sustainable development. "Scientific knowledge is strongest when it reflects diverse perspectives," Prof. Djimdé said in response to the appointment, "and I look forward to contributing African experience and expertise to conversations shaping the future of global health and development."

The 4 Pillars of the Grand Challenges Ecosystem
Innovation happens all along the journey from idea, to experiment, to product or policy, and finally to delivery at scale in communities. We fund innovation projects while supporting an environment of champions, systems, and partnerships to maximize the impact these projects make in people's lives.
Innovations
Grand Challenges funds innovations to tackle the biggest problems in global health and development. Since 2004, through the Grand Challenges program, we have supported more than 2500 innovation projects in more than 90 countries.
Champions
Grand Challenges supports exceptional scientists with the expertise to do breakthrough R&D as well as the experience, networks, and skills to excel as scientific leaders. These champions co-create projects with global partners, mobilize key institutions in their countries, and improve public health in their communities and around the world.
Partnerships
For more than 20 years, Grand Challenges has built trusted relationships with global health funders and researchers. We tap into this powerful network to create unique scientific collaborations with a transformative impact on people's lives.
Systems
Doing groundbreaking science requires the right mix of institutions, policies, and tools. Grand Challenges works with partners in low- and middle-income countries to build or strengthen the capacities they need to succeed in R&D.